Eficacia da Estimulacao Magnetica Transcraniana no Bipolar em Mania

Eficacia da Estimulacao Magnetica Transcraniana no Bipolar em Mania de Centro Brasileiro de Estimulacao Magnetica Transcraniana

Por: Centro Brasileiro de Estimulacao Magnetica Transcraniana  10/09/2009
Palavras-chave: Depressão, Depressao, Estimulação Magnética

 Efficacy of high frequency (rapid) suprathreshold repetitive transcranial magnetic stimulation of right prefrontal cortex in bipolar mania: A randomized sham controlled study
Volume 117, Issue 3, Pages 146-150 (October 2009)
Samir Kumar Praharaja, Daya Rama, Manu Arorab

Abstract ObjectiveTo examine the efficacy of adjunctive right prefrontal high-frequency suprathreshold rTMS treatment in bipolar affective disorder, mania patients as compared to sham stimulation.Method41 right handed bipolar mania patients were randomized to receive daily sessions of active or sham rTMS (20 Hz, 110% of MT, 20 trains, 10 s intertrain interval) over the right dorsolateral prefrontal cortex for 10 days. Mania was rated using Young Mania Rating Scale (YMRS) and Clinical Global Impression (CGI) at baseline, and after 5th and 10th rTMS.Result For YMRS scores, repeated measures ANOVA showed a significant effect of treatment over time as shown by interaction effect (F = 12.95, df = 1.51/58.94, p < 0.001, Greenhouse-Geisser corrected). For CGI-S, repeated measures ANOVA showed a significant interaction effect of treatment over time (F = 5.34, df = 1.36/53.01, p = 0.016, Greenhouse-Geisser corrected).Conclusion High-frequency supra-threshold right prefrontal rTMS in bipolar, mania patients was well tolerated and found to be effective as add-on to standard pharmacotherapy.
Keywords: Bipolar affective disorder, Mania, rTMS

Palavras-chave: Depressao, Depressão, EMTr, Estimulação Magnética, Estimulacao Magnetica Transcraniana, Transtornos Do Humor

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