EMTr e depressão: Influence of repetitive transcranial magnetic stimulation on psychomotor symptoms in major depression.
Psychomotor symptoms related to an impairment of the nigrostriatal dopaminergic system are frequent in major depression (MD). Repetitive transcranial magnetic stimulation (rTMS) has been discussed as a new treatment option for MD. In neurobiological terms, an influence of high-frequency rTMS on dopaminergic neurotransmission has previously been shown by several studies in animals and humans. Therefore, an improvement of psychomotor symptoms by rTMS could be assumed. The aim of this pilot study was to investigate the effect of high-frequency rTMS on psychomotor retardation and agitation in depressive patients. We investigated the effect of left prefrontal 10 Hz rTMS on psychomotor retardation and agitation in 30 patients with MD. Patients were randomly assigned to real or sham rTMS in addition to a newly initiated standardized antidepressant medication. We found a trend in the reduction of agitation (t (28) = 1.76, p = 0.09, two-tailed), but not in the reduction of retardation. Furthermore, no general additional antidepressant effect of rTMS was observed.
Eur Arch Psychiatry Clin Neurosci. 2009 Aug 13. Hoeppner J, Padberg F, Domes G, Zinke A, Herpertz SC, Großheinrich N, Herwig U. Department of Psychiatry and Psychotherapy, Center of Nervous Diseases, University of Rostock, Gehlsheimer Str. 20, 18147, Rostock, Germany, [email protected]