Dissociating cognitive from affective theory of mind: A TMS study.

Por: Estimulação Magnética Transcraniana repetitiva (EMTr)  05/12/2009
Palavras-chave: Depressão, Psiquiatria, Transtornos Psiquiátricos

                         Dissociating cognitive from affective theory of mind: A TMS study.

INTRODUCTION: "Theory of Mind" (ToM), i.e., the ability to infer other persons' mental states, is a key function of social cognition. It is increasingly recognized to form a multidimensional construct. One differentiation that has been proposed is that between cognitive and affective ToM, whose neural correlates remain to be identified. We aimed to ascertain the possible role of the right dorsolateral prefrontal cortex (DLPFC) for cognitive ToM as opposed to affective ToM processes. METHODS: 1Hz repetitive transcranial magnetic stimulation (rTMS) was used to interfere offline with cortical function of the right DLPFC in healthy male subjects who subsequently had to perform a computerized task assessing cognitive and affective ToM. RESULTS: RTMS over the right DLPFC induced a selective effect on cognitive but not affective ToM. More specifically, a significant acceleration of reaction times in cognitive ToM compared to affective ToM and control items was observed in the experimental (right DLPFC) compared to the control (vertex) rTMS stimulation condition. 

Kalbe E, Schlegel M, Sack AT, Nowak DA, Dafotakis M, Bangard C, Brand M, Shamay-Tsoory S, Onur OA, Kessler J. Cortex. 2009 Jul 29

Palavras-chave: Antidepressivo, Depressão, EMTr, Estimulação Magnética, Psiquiatria, Transtornos Psiquiátricos, Tratamento com Estimulação magnética

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