Characterising the application of transcranial direct current stimulation in human pharyngeal motor

Por: Eletroconvulsoterapia - IPAN (Instituto de Pesquisas Avançadas em Neuroestimulação)  17/10/2009
Palavras-chave: Sono, Estimulação, Antidepressivo

 Characterising the application of transcranial direct current stimulation in human pharyngeal motor cortex.
Objectives Transcranial direct current stimulation (tDCS) is a novel intervention that can modulate brain excitability in health and disease, however, little is known about its effects on bilaterally innervated systems such as pharyngeal motor cortex. Here, we assess the effects of differing doses of tDCS on the physiology of healthy human pharyngeal motor cortex as a prelude to designing a therapeutic intervention in dysphagic patients. Methods Healthy subjects (n=17) underwent seven regimens of tDCS (Anodal 10minutes 1mA, Cathodal 10minutes 1mA, Anodal 10minutes 1.5mA, Cathodal 10minutes 1.5mA, Anodal 20minutes 1mA, Cathodal 20minutes 1mA, Sham) on separate days, in a double blind randomised order. Bihemispheric motor evoked potential (MEP) responses to single-pulse transcranial magnetic stimulation (TMS) as well as intracortical facilitation (ICF) and inhibition (ICI) were recorded using a swallowed pharyngeal catheter before and up to 60 minutes following the tDCS. Results Compared to sham, both 10 minute 1.5mA and 20 minute 1mA anodal stimulation induced increases in cortical excitability in the stimulated hemisphere (+44 +/-17% and +59 +/-16% respectively, p<0.005) whereas only 10min 1.5mA cathodal stimulation induced inhibition (-26 +/-4%, p=0.02). There were neither contralateral hemisphere changes nor any evidence for ICI or ICF in driving the ipsilateral effects. 1: Am J Physiol Gastrointest Liver Physiol. 2009 Oct 8. [Epub ahead of print]Jefferson S, Mistry S, Singh S, Rothwell JC, Hamdy S.

Palavras-chave: Antidepressivo, Eletroconvulsoterapia - Ect, EMTr, Estimulação, Estimulação Magnética Transcraniana, Neuroestimulação, Sono

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